Warning:
JavaScript is turned OFF. None of the links on this page will work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: steps to pathogenicity, indirect= not the pathogen itself causing damage, but the toxin it produces exotoxins- toxin produced inside of bacterial cell, then released most exotoxins produced by gram + bact & plasmids (plasmids spread quickly), cytotoxins target ribosome, halts protein synth. ex. diptheria, Steps to pathogenicity 2. adherance surface molecules on pathogens bind to host receptors, bacterial enzymes hyaluronidase breaks down hyaluronic acid which is "connective tissue glue", helps bact to spread, Steps to pathogenicity 3. penetration bacterial enzymes, Steps to pathogenicity 1. entry Portals of entry: intact skin, nonintact skin (parenteral), mucous membranes (GI, repiratory, urogential), bacterial enzymes leukocidins white blood cell killer, Steps to pathogenicity 4. damage to host cell Direct damage= the organism itself causes damage, Steps to pathogenicity 4. damage to host cell indirect= not the pathogen itself causing damage, but the toxin it produces, cell wall components example m protein in cell wall aids in attachment and resists phagocytocis (in strep pyo); waxy cell wall resists phagocytosis in myco tuberculosis, bacterial enzymes kinases stops coagulation, helping spread bact & can get deeper into tissue, indirect= not the pathogen itself causing damage, but the toxin it produces exotoxins- toxin produced inside of bacterial cell, then released enterotoxin, Steps to pathogenicity 3. penetration capsule- prevents phagocyte from binding to bacteria, Steps to pathogenicity 3. penetration cell wall components, indirect= not the pathogen itself causing damage, but the toxin it produces endotoxins most are gram - LPS part of cell wall, all produce same basic symptoms- hypotension, sepsis, dec. HR, shock, coma death, Steps to pathogenicity 1. entry pathogens have preferred portals of entry. Must have sufficient # of organisms called "Infectious Dose", bacterial enzymes coagulases causes coag. of blood, walling itself off -immune system doesn't see, indirect= not the pathogen itself causing damage, but the toxin it produces exotoxins- toxin produced inside of bacterial cell, then released neurotoxin= usually affects impulse transmission, does not usually kill cell, neurotoxin= usually affects impulse transmission, does not usually kill cell ex. botulinum, tetanus, indirect= not the pathogen itself causing damage, but the toxin it produces exotoxins- toxin produced inside of bacterial cell, then released cytotoxins target ribosome, halts protein synth.